Search results for "Polycyclic cage compounds"

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Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

2008

Graphical abstract Several bisnoradamantylamines and noradamantylamines have been synthesized and their antiviral, trypanocidal, NMDA receptor antagonist, and dopamine reuptake inhibitory activities have been studied.

RimantadineStereochemistryDopamineeducationClinical BiochemistryPharmaceutical Sciencemacromolecular substancesPharmacologymedicine.disease_causeAntiviral AgentsReceptors N-Methyl-D-AspartateBiochemistryChemical synthesisArticleInhibitory Concentration 50DogsPolycyclic compoundMemantineTrypanosomiasisDopamineDrug DiscoveryAmantadinemedicineInfluenza A virusAnimalsNMDA receptor antagonistMolecular BiologyCells Culturedchemistry.chemical_classificationChemistryOrganic ChemistryAmantadinePolycyclic cage compoundsBiological activityInfluenzanervous systemInfluenza A virusMolecular MedicineNMDA receptormedicine.drugBioorganic & Medicinal Chemistry

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
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  - PE2_6Nuclear, hadron and heavy ion physics
  - PE2_8Gas and plasma physics
  - PE2_5Classical and quantum physics of gravitational interactions
  - PE2_7Nuclear and particle astrophysics
  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
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  - PE2_13Quantum optics and quantum information
  - PE2_15Thermodynamics
- PE1Mathematics
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  - PE1_6Geometry and global analysis
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  - PE1_12Mathematical physics
  - PE1_11Theoretical aspects of partial differential equations
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  - PE1_15Generic statistical methodology and modelling
  - PE1_4 Algebraic and complex geometry
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  - PE1_2Algebra
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  - PE10_14Earth observations from space/remote sensing
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  - PE10_13Physical geography, geomorphology
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  - PE11_2Engineering of metals and alloys
  - PE11_1Engineering of biomaterials, biomimetic, bioinspired and bio-enabled materials
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  - PE11_12Semi-conducting and magnetic materials engineering
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LSLife Sciences
- LS1Molecules of Life: Biological Mechanisms, Structures and Functions
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  - LS1_1Macromolecular complexes including interactions involving nucleic acids, proteins, lipids and carbohydrates
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  - LS1_6Glycobiology
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  - LS1_12Protein design
  - LS1_13Early translational research and drug design
  - LS1_14Innovative methods and modelling in molecular, structural and synthetic biology
  - LS1_10Synthetic biology
  - LS1_8Structural biology
  - LS1_9Molecular mechanisms of signalling processes
  - LS1_7Molecular biophysics, biomechanics, bioenergetics
- LS2Integrative Biology: from Genes and Genomes to Systems
  - LS2_1Genetics
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  - LS2_2Gene editing
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  - LS2_16Innovative methods and modelling in integrative biology
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- LS4Physiology in Health, Disease and Ageing
  - LS4_1Organ and tissue physiology and pathophysiology
  - LS4_4Endocrinology
  - LS4_3Physiology of ageing
  - LS4_2Comparative physiology
  - LS4_5Non-hormonal mechanisms of inter-organ and tissue communication
  - LS4_6Microbiome and host physiology
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  - LS3_7Mechanobiology of cells, tissues and organs
  - LS3_8Embryogenesis, pattern formation, morphogenesis
  - LS3_9Cell differentiation, formation of tissues and organs
  - LS3_10Developmental genetics
  - LS3_11Evolution of developmental strategies
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  - LS3_3Cell behaviour, including control of cell shape, cell migration
  - LS3_13Stem cells
  - LS3_14Regeneration
  - LS3_15Development of cell-based therapeutic approaches for tissue regeneration
  - LS3_17Theoretical modelling in cellular, developmental and regenerative biology
  - LS3_16Functional imaging of cells and tissues
  - LS3_1Cell cycle, cell division and growth
  - LS3_2Cell senescence, cell death, autophagy, cell ageing
- LS5Neuroscience and Disorders of the Nervous System
  - LS5_1Neuronal cells
  - LS5_3Neural development and related disorders
  - LS5_5Neural networks and plasticity
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  - LS5_4Neural stem cells
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  - LS9_7Environmental biotechnology and bioengineering
  - LS9_8Applied plant sciences, plant breeding, agroecology and soil biology
  - LS9_10Veterinary and applied animal sciences
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  - LS9_1Bioengineering for synthetic and chemical biology
SHSocial Sciences and Humanities
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  - SH5_4Philology; text and image studies
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